Read the full press release (US Environmental Protection Agency)

WASHINGTON – Today, the U.S. Environmental Protection Agency (EPA) issued the next Toxic Substances Control Act (TSCA) test order requiring testing on per- and polyfluoroalkyl substances (PFAS) under EPA’s the National PFAS Testing Strategy. Today’s action orders companies to conduct and submit testing on trifluoro(trifluoromethyl)oxirane (HFPO), a perfluoroalkyl substance used in making plastics. This is the second test order under the strategy and the latest action taken under EPA’s PFAS Strategic Roadmap to confront contamination from forever chemicals nationwide.

The information EPA receives under this order will not only improve the Agency’s understanding of human health effects of HFPO, but also the effects of dozens of PFAS that are structurally similar to HFPO and in the same Testing Strategy category of PFAS, improving the agency’s overall data on PFAS. 

‘PFAS can pose a serious risk to communities, especially those overburdened with pollution, but many of these chemicals have limited or no toxicity data. That’s why we’re working quickly to establish stronger, more robust data on PFAS to better understand and ultimately reduce the potential risks,’ said Assistant Administrator for the Office of Chemical Safety and Pollution Prevention Michal Freedhoff. ‘Communities deserve transparency from the companies that use or produce these substances and we’ll continue to use our data-gathering tools to collect information on the potential environmental and human health impacts of PFAS like HFPO.’

HFPO (CASRN 428-59-1) is used in making plastics and in organic chemical manufacturing. More than 1,000,000 pounds of HFPO are manufactured each year, according to TSCA Chemical Data Reporting rule reports.

After thoroughly examining existing hazard and exposure data, EPA has concluded that HFPO may present an unreasonable risk of injury to health or the environment. The potential hazards from exposure to this chemical could include neurotoxicity, reproductive effects and cancer. EPA also found there is insufficient information to determine the effects on human health from inhalation of HFPO (which is a gas at room temperature). This test order will address this data need.

The Chemours Company FC LLC, DuPont De Nemours Inc., E. I. du Pont de Nemours and Company, and 3M Company are the recipients of this test order. Prior to issuing the test order, EPA engaged in discussions with the recipient companies to encourage them to voluntarily submit existing data on HFPO to EPA. Based on information in existing studies provided by cooperating companies, EPA determined that certain data were no longer needed and thus excluded the relevant testing requirements from the issued order. EPA has made the data voluntarily provided by these companies publicly available in docket EPA-HQ-OPPT-2021-0910 on” …